Identification of aminopyrimidine regioisomers via line broadening effects in ¹H and ¹³C NMR spectroscopy

Title: Identification of aminopyrimidine regioisomers via line broadening effects in ¹H and ¹³C NMR spectroscopy
Creator: Garner, James; Hill, Tim; Odell, Luke; Keller, Paul; Morgan, Jody; McCluskey, Adam
Relation: Australian Journal of Chemistry Vol. 57, Issue 11, p. 1079-1083
Publisher Link: http://dx.doi.org/10.1071/CH03316
Publisher: CSIRO Publishing
Resource Type: journal article
Date: 2004
Description: Substituted mono- and diamino-pyrimidines were synthesized as part of our medicinal chemistry programmes. Primary amines substituted at the 4-position exhibited room-temperature line broadening effects in both ¹H and ¹³C NMR spectroscopy due to the presence of rotamers, but these effects were not observed for substituents in the 2-position. This provided a simple diagnostic tool for the identification of regioisomers, a determination which would otherwise have required two-dimensional experiments.
Subject: mono-pyrimidines; diamino-pyrimidines; amines; ¹H and ¹³C NMR spectroscopy; regioisomers
Identifier: http://hdl.handle.net/1959.13/33618
Identifier: uon:3267
Identifier: ISSN:0004-9425
Language: eng
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